Animal-Free Recombinant Murine GDNF
货号：AF-450-44-10,AF-450-44-100,AF-450-44-1000,AF-450-44-2,AF-450-44-250,AF-450-44-500
规格：10ug,100ug,1mg,2ug,250ug,500ug
价格：2830,21940,87780,1250,38400,57050
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer consisting of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Murine GDNF is 30.2 kDa.Manufactured using all Animal-Free reagents.来源:E.coli别名:Glial-Derived Neurotrophic Factor, ATF-1氨基酸序列:MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by the proliferation of rat C6 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106units/mg.Calculated Molecular Weight:30.2 kDaAccession Number:P48540Gene ID:14573交叉反应:Rat原产国:USA |
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