Recombinant Human TGF-β1 (HEK293 derived)
货号：100-21-10,100-21-100,100-21-1000,100-21-2,100-21-250,100-21-50,100-21-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格：1560,12176,48759,640,21291,7297,31632
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述:The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts, and recently it has been implicated in the formation of skin tumors. Recombinant Human TGF-β1 derived fromHEK293 cellsis a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.别名:Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor氨基酸序列:ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS来源:HEK293 cells纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.交叉反应:Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat, Human, Mink, Donkey, N/A, Mouse + Virus原产地:USA仅用于研究。不适用于诊断或治疗。 |
product.subtitle.recentcitations |
第一作者 | Bai, W |
标题 | The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. |
文献引用 | Cell Reports; 36(13) pg109756 |
PubMed Id | 334592150 |
第一作者 | Wigton, E J |
标题 | MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination. |
文献引用 | The Journal of Experimental Medicine; 218(11) |
PubMed Id | 34586363 |
第一作者 | Yu, H |
标题 | Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15. |
文献引用 | Blood; 92(10) pg3647-57 |
PubMed Id | 9808558 |
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