Integrin beta 5 Monoclonal Antibody (KN52), FITC

货号：11-0497-41,11-0497-42

规格：25 Tests,100 Tests

价格：1132,2892

产品类型：流式抗体

品牌：eBioscience

物种：人/小鼠

宿主：小鼠

抗体亚型：IgG

克隆号：KN52

荧光染料：FITC

类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC
浓度：	5 µL/Test	用法：	5 μL (0.125 μg)/test(Flow)

产品详细信息Description: The KN52 antibody reacts with human integrin beta 5, an approximately 100,000 Mr (reduced) and 95,000 Mr (nonreduced) a member of the integrin family. Only a single alpha chain, the alpha v subunit, associates with the integrin beta 5 to form the vitronectin receptor complex. Integrin alpha v/beta 5 complex also binds to the basic domain of Tat (he sequence RKKRRQRRR). The integrin beta 5 is found on carcinoma cell lines, hepatoma and fibroblast cell lines, and is absent from lymphoblastoid cells and platelets.The KN52 monoclonal antibody has been shown to inhibit migration.Applications Reported: This KN52 antibody has been reported for use in flow cytometric analysis.Applications Tested: This KN52 antibody has been pre-titrated and tested by flow cytometric analysis of Chinese Hamster Ovary (CHO), A549 and normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need tocluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.

数据

Integrin beta 5 Antibody (11-0497-41)Proceedings of the National Academy of Sciences of the United States of America 2016 -Published figure using Integrin beta 5 monoclonal antibody (Product # 11-0497-41）

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参考文献：

1.Proceedings of the National Academy of Sciences of the United States of AmericaComplex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes."Published figure using Integrin beta 5 monoclonal antibody (Product # 11-0497-42) in Flow Cytometry"2.Cell communication and signaling : CCSInhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression."Published figure using Integrin beta 5 monoclonal antibody (Product # 11-0497-42) in Neutralization"3.NeuronDevelopment of a method for the purification and culture of rodent astrocytes."Published figure using Integrin beta 5 monoclonal antibody (Product # 11-0497-42) in Immunocytochemistry"4.NeuronDevelopment of a method for the purification and culture of rodent astrocytes."Published figure using Integrin beta 5 monoclonal antibody (Product # 11-0497-42) in Immunocytochemistry"5.Cancer researchMacrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.AuthorsSangaletti S,Di Carlo E,Gariboldi S,Miotti S,Cappetti B,Parenza M,Rumio C,Brekken RA,Chiodoni C,Colombo MP

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