CD49b (Integrin alpha 2) Monoclonal Antibody (eBioY418 (Y418)), FITC

货号：11-0498-41,11-0498-42

规格：25 Tests,100 Tests

价格：1629,2055

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：小鼠

抗体亚型：IgG

克隆号：eBioY418 (Y418)

荧光染料：FITC

类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC
浓度：	5 µL/Test	用法：	5 μL (0.125 μg)/test(Flow)

产品详细信息Description: The eBioY418 (Y418) monoclonal antibody reacts with human CD49b, the 150-kDa, integrin alpha 2 subunit. The complex of CD49b non-covalently associated with integrin beta 1 (CD29), also known as VLA-2, is a receptor for collagen and laminin. This complex is expressed by lymphocytes, activated T cells, monocytes and platelets.Applications Reported: This eBioY418 (Y418) antibody has been reported for use in flow cytometric analysis.Applications Tested: This eBioY418 (Y418) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles inVEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

数据

CD49b (Integrin alpha 2) Antibody (11-0498-41) in FlowStaining of normal human peripheral blood cells withMouse IgG2b K Isotype Control FITC (Product # 11-4732-42) (blue histogram) or Anti-Human CD49b (Integrin alpha2) FITC (purple histogram). Cells in the lymphocytegate were used for analysis.

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参考文献：

1.Stem cells (Dayton, Ohio)Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells. AuthorsMenon V,Thomas R,Elgueta C,Horl M,Osborn T,Hallett PJ,Bartos M,Isacson O,Pruszak J2.BioMed research internationalMelanoma cells homing to the brain: an in vitro model."11-0498 was used in Flow cytometry/Cell sorting to reveal that matrix metalloproteinase proteins could be directly involved in blood brain barrier permeability and that brain invasion by melanoma cells could be related to their expression."AuthorsRizzo A,Vasco C,Girgenti V,Fugnanesi V,Calatozzolo C,Canazza A,Salmaggi A,Rivoltini L,Morbin M,Ciusani E

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