PAX2 Polyclonal Antibody/PAX2多克隆抗体

货号：71-6000

规格：100 µg

价格：4809

产品类型：免疫组化一抗

品牌：Thermo Fisher

抗原：A GST-Pax-2 fusion protein derived from the C-term

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	多抗	同型对照：
浓度：	0.25 mg/mL	用法：	Assay Dependent(ELISA)；Assay Dependent(IF)；Assay Dependent(IHC)；Assay Dependent(IP)；Assay Dependent(WB)

靶标信息The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, andpax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.仅用于科研。不用于诊断过程。未经明确授权不得转售。

数据

PAX2 Antibody (71-6000) in WBWestern blot of mouse embryonic kidney using Rabbit anti-Pax-2 Polyclonal Antibody (Product # 71-6000).

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参考文献：

1 Frontiers in neuroanatomyThe Temporal Contribution of theGbx2Lineage to Cerebellar Neurons.2 PainMorphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn.3 Advanced healthcare materialsFunctional Kidney Bioengineering with Pluripotent Stem-Cell-Derived Renal Progenitor Cells and Decellularized Kidney Scaffolds.4 NatureKidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.5 Development (Cambridge, England)A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord.

技术参数

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