CD61 (Integrin beta 3) Monoclonal Antibody (VI-PL2), eBioscience™/CD61 (Integrin beta 3) 单克隆 (VI-PL2)流式抗体，eBioscience™

货号：14-0619-82,14-0619-37,14-0619-95

规格：100 µg,1 mg,10 mg

价格：1283,11562,28906

产品类型：流式抗体

品牌：eBioscience

抗原：CD61

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：VI-PL2

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	IgG1, kappa
浓度：	1 mg/mL	用法：	0.125 µg/test（Flow）;Assay-Dependent（WB）;Assay-Dependent（功能检测）

产品详细信息Description: The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells.This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey.Applications Reported: This VI-PL2 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, immunohistochemical staining, and functional assays.Applications Tested: This VI-PL2 antibody has been tested by flow cytometric analysis of human peripheral blood platelets. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.仅用于科研。不用于诊断过程。

数据

CD61 (Integrin beta 3) Antibody (14-0619-82) in FlowStaining of normal human peripheral blood platelets with 0.06 µg of Mouse IgG1 kappa Isotype Control Purified (Product # 14-4714-82) (left) or 0.06 µg of Anti-Human CD61 (Integrin beta 3) Purified (right) followed by 'F (ab')2 Anti-Mouse IgG PE (Product # 12-4012) followed by Anti-Human CD42b FITC (Product # 11-0429-42).

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