CD38 Monoclonal Antibody (90), Functional Grade, eBioscience™/CD38 单克隆 (90), 功能抗体, eBioscience™

货号：16-0381-85,16-0381-38,16-0381-025,16-0381-050

规格：500 µg,5 mg,25 mg,50 mg

价格：3326,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD38

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号：90

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.125 µg/test（Flow）；Assay-Dependent（FN）

产品详细信息Description: The 90 monoclonal antibody reacts with the mouse CD38 molecule, an ~42 kDa type II transmembrane protein. CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. Its expression is reported on a subpopulation of thymocytes, mature T cells, and NK cells. Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhancedby co-signals such as IL-4 and LPS. CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a role in lymphocyte activation and differentiation.Applications Reported: The 90 antibody has been reported for use in flow cytometric analysis and functional assays.Applications Tested: The 90 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.仅用于科研。不用于诊断过程。

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参考文献：

流式1.Proceedings of the National Academy of Sciences of the United States of AmericaTracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting."16-0381 was used in Flow cytometry/Cell sorting to study gene function specifically in germinal centre B cells using Cγ1-cre knockin mice."AuthorsCasola S,Cattoretti G,Uyttersprot N,Koralov SB,Seagal J,Segal J,Hao Z,Waisman A,Egert A,Ghitza D,Rajewsky K2.Scientific reportsInterleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells."16-0381 was used in Flow cytometry/Cell sorting to suggest that insufficient IL-35 levels play a pivotal role in the development of T1D and that treatment with IL-35 should be investigated in treatment of T1D and other autoimmune diseases."AuthorsSingh K,Kadesjö E,Lindroos J,Hjort M,Lundberg M,Espes D,Carlsson PO,Sandler S,Thorvaldson L3.Genes and developmentThe E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis."16-0381 was used in Flow cytometry/Cell sorting to show that Id2 and Id3 suppress the development and expansion of innate variant follicular helper T cells."AuthorsMiyazaki M,Miyazaki K,Chen S,Chandra V,Wagatsuma K,Agata Y,Rodewald HR,Saito R,Chang AN,Varki N,Kawamoto H,Murre C4.Molecular and cellular biologyCritical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity."16-0381 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases."AuthorsZhong MC,Veillette AFN5.Journal of immunology (Baltimore, Md. : 1950)The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling."16-0381 was used in Functional assays to display the importance of balance between kinases and phosphatases for immune cell function."AuthorsAlsadeq A,Hobeika E,Medgyesi D,Kläsener K,Reth M

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