CD158a/h/g Monoclonal Antibody (HP-MA4), PE
货号：12-1589-42
规格：100 Tests
价格：2580
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG2b, kappa
荧光染料：PE
| 抗体类型 | 单抗 | 同型对照： | Mouse IgG2b kappa Isotype Control (eBMG2b), PE |
| 浓度： | 5 µL/Test | 用法： | 5 µL (0.25 µg)/test(Flow) |
| 产品详细信息Description: The monoclonal antibody HP-MA4 recognizes several CD158 proteins, also known as KIR2D, specifically KIR2DL1 (CD158a), KIR2DS1 (CD158h), KIR2DS3, and KIR2DS5 (CD158g). It does not recognize KIR2DL2 (CD158b1), KIR2DS2 (CD158j), KIR2DL4 (CD158d) or KIR2DS4 (CD158i) and crossreactivity to KIR2DL3 (CD158b2) and KIR2DL5 (CD158f) are unknown. CD158 proteins are members of the killer cell immunoglobulin-like receptors (KIR) family of transmembrane glycoproteins that are expressed on NK cells and a subset of T cells. Each KIR has an isoform with either a short (S) or long (L) cytoplasmic domain which transduces either an activating or inhibitory signal, respectively. The crossreactivity of the HP-MA4 antibody to KIR2DS3 and KIR2DS5 was published in 2013.Applications Reported: This HP-MA4 antibody has been reported for use in flow cytometric analysis.Applications Tested: This HP-MA4 antibody has been pre-titrated and tested hy flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. |
| 数据 |
| CD158a/h/g Antibody (12-1589-42) in FlowStaining of normal human peripheral blood cells with Anti-Human CD56 (NCAM) APC (Product # 17-0567-42) and Mouse IgG2b K Isotype Control PE (Product # 12-4732-81) (left) or Anti-Human CD158a/h/g PE (right). Cells in the lymphocyte gate were used for analysis. |
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| 参考文献： |
| 1.Genes and immunityA comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs.AuthorsCzaja K,Borer AS,Schmied L,Terszowski G,Stern M,Gonzalez A2.Genes and immunityA comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs.AuthorsCzaja K,Borer AS,Schmied L,Terszowski G,Stern M,Gonzalez A |
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