santacruz GSK-3 Inhibitor X分子量: 398.2分子式: C18H12BrN3O3可溶性: Soluble in DMSO
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santacruz GSK-3 Inhibitor Xsantacruz GSK-3 Inhibitor X详细产品信息：
| GSK-3 Inhibitor X (CAS 740841-15-0) |
5 5 (Based on popularity) 1 | Synonym: | BIO-Acetoxime; 6-Bromoindirubin-3′-acetoxime, BIA | | Application: | A selective GSK-3α/β inhibitor | | CAS Number: | 740841-15-0 | | Purity: | ≥95% | | Molecular Weight: | 398.21 | | Molecular Formula: | C18H12BrN3O3 | | Refer to Certificate of Analysis for lot specific data (including water content). |
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| GSK-3 Inhibitor X | sc-221689 | 1 mg | $115 | | Add | |
Description GSK-3 Inhibitor X is an acetoxime analog of BIO which acts as a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). GSK-3 Inhibitor X induces Wnt signaling and inhibits CD8+ T cell effector differentiation. Technical Information | Physical State: | Solid | | Solubility: | Soluble in DMSO (10 mg/ml). | | Storage: | Store at 4° C | | Melting Point: | 236.83 °C (Predicted) | | Boiling Point: | 551.87 °C (Predicted) | | Density: | 1.69 g/cm3 (Predicted) | | Refractive Index: | n20D 1.74 (Predicted) | | IC50: | GSK-3α/β: IC50 = 10 nM; Cdk5/p25: IC50 = 2.4 µM; Cdk2/A: IC50 = 4.3 µM; Cdk1/B: IC50 = 63 µM; Cdk4/D1: IC50 = ≥10 µM; aryl hydrocarbon receptor: EC5050 = ≥0.1 µM (yeast); aryl hydrocarbon receptor: EC5050 = 0.16 µM (mammalian) | | pK Values: | pKa: 9.23 (Predicted) |
Safety and Reference Information | PubChem CID: | 6538818 | | MDL Number: | MFCD09037533 | | SMILES: | CC(=O)ONC1=C2C=CC=CC2=NC1=C3C4=C(C=C(C=C4)Br)NC3=O |
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
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