IDE1

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IDE1

货号:1164899-10,1164899-1

规格:10mg,1mg

价格:2090,605

产品类型:小分子化合物

品牌:Biogems

Catalogue Number :1164899

Description

IDE1 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.

Additional Information

Applications

FA

Synonyms:

1DE 1, Inducer of Definitive Endoderm 1

Formulation:

Crystalline solid

Chemical Name:

1-[2-[(2-carboxyphenyl)methylene]hydrazide]-heptanedioic acid

Molecular Formula:

C15H18N2O5

Molecular Weight:

306.3

CAS Number

1160927-48-9

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Hoveizi, E., Nabiuni, M., Parivar, K., Ai, J., & Massumi, M. (2014). Definitive endoderm differentiation of human‐induced pluripotent stem cells using signaling molecules and IDE1 in three‐dimensional polymer scaffold.Journal of Biomedical Materials Research Part A,102(11), 4027-4036.

Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., ... & Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.Cell stem cell,4(4), 348-358.

Aguayo-Mazzucato, C., & Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus.Nature Reviews Endocrinology,6(3), 139-148.

技术参数
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