Recombinant Human/Murine/Rat BMP-2 (E.coli derived)
货号：120-02-2,120-02-250,120-02-50,120-02-500,120-02-10,120-02-100,120-02-1000
规格：2ug,250ug,50ug,500ug,10ug,100ug,1mg
价格：640,15974,5475,23727,1560,9126,36565
产品类型：细胞因子添加物
品牌：PeproTech
| 产品详情产品编号：120-02产品描述：BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, and is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate, ovary, and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant Human/Murine/Rat BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.Source:E.coliSynonyms:Bone Morphogenetic Protein-2, BMP-2AAA Sequence (monomer):MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCRPurity:≥ 98% by SDS-PAGE gel and HPLC analyses.Biological Activity:Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expectedED50for this effect is 0.5-1.0 μg/ml.Calculated Molecular Weight:26 kDaAccession Number:P12643Gene ID:650crossreactivity: Alpaca,Cow,Dog,Gelatin Microparticles,Human,Monkey,Mouse,Rabbit,Rat Country Of Origin:USA Not for human use. |
| product.subtitle.recentcitations |
| 第一作者 | Jokoji, G |
| 标题 | CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1 |
| 文献引用 | The Journal of Biological Chemistry; 297(2) pg100994PubMed Id |
| PubMed Id | 34298017 |
| 第一作者 | Grotheer, V |
| 标题 | Osteogenic differentiation of human mesenchymal stromal cells and fibroblasts differs depending on tissue origin and replicative senescence. |
| 文献引用 | Scientific Reports; 11(1) pg11968PubMed Id |
| PubMed Id | 34099837 |
| 第一作者 | Geng, Y |
| 标题 | BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways. |
| 文献引用 | Communications Biology; 4(1) pg82PubMed Id |
| PubMed Id | 33469143 |
©
Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：
https://biorod.cn/thread-14648.htm
QQ:1749072012