Recombinant Murine IL-21
货号：210-21-10,210-21-100,210-21-1000,210-21-2,210-21-250,210-21-50,210-21-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格：1418,11069,44326,582,19355,6634,28757
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T cell-stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues.来源:E.coli别名:Interleukin-21, Za11氨基酸序列:MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Assay #1:Measured by its ability to induce STAT3 signaling in U937 Stat3-Luc reporter cells.Assay #2:Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expectedED50is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.Calculated Molecular Weight:15 kDaAccession Number:Q9ES17Gene ID:60505交叉反应：Human,Mouse原产国:USA |
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