Recombinant Human sCD40 Ligand
货号：310-02-10,310-02-100,310-02-1000,310-02-250,310-02-50,310-02-500
规格：10ug,100ug,1mg,250ug,50ug,500ug
价格：582,3187,12787,5581,1418,8292
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述:CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generatedin vivoby an intracellular proteolytic processing of the full length CD40L. Recombinant Human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.别名:soluble CD40 Ligand, TNFSF5, TRAP, CD154, Gp39, T-BAM氨基酸序列:MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL来源:E.coli纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:Assay #1:Determined by the stimulation of IL-12 induction by human PBMCs.Assay #2:Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The expectedED50for this effect is 5-10 ng/ml.Note: Results may vary with PBMC donors.Calculated Molecular Weight:16.3 kDaAccession Number:P29965Gene ID:959交叉反应:Monkey, Mouse, Human, Bacteria原产地:USA仅用于科研，不能用于临床和诊断。 |
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