Recombinant Human Adiponectin
货号：450-24-5,450-24-100,450-24-1000,450-24-25,450-24-250,450-24-500
规格：5ug,100ug,1mg,25ug,250ug,500ug
价格：1050,13470,80080,2570,33670,52050
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant Human Adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35.0 kDa by SDS PAGE analysis under reducing conditions. The calculated molecular weight of Recombinant Human Adiponectin is 25.9 kDa.来源:Hi-5 Insect cells别名:Acrp-30, GBP-28, APM-1, Gelatin-binding protein, AdipoQ氨基酸序列:RGHHHHHHHH ETTTQGPGVL LPLPKGACTG WMAGIPGHPG HNGAPGRDGR DGTPGEKGEK GDPGLIGPKG DIGETGVPGA EGPRGFPGIQ GRKGEPGEGA YVYRSAFSVG LETYVTIPNM PIRFTKIFYN QQNHYDGSTG KFHCNIPGLY YFAYHITVYM KDVKVSLFKK DKAMLFTYDQ YQENNVDQAS GSVLLHLEVG DQVWLQVYGE GERNGLYADN DNDSTFTGFL LYHDTN纯度:≥ 97% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by a cytotoxic assay using M1 cells. TheED50for this effect is 3.0-6.0 μg/ml.Calculated Molecular Weight:25.9 kDaAccession Number:Q15848Gene ID:9370交叉反应:Human,Mouse,Rat原产国:USA |
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