Recombinant Human BMP-6
货号：120-06-2,120-06-10,120-06-100,120-06-1000,120-06-250,120-06-50,120-06-500
规格：2ug,10ug,100ug,1mg,250ug,50ug,500ug
价格：640,1560,12176,48759,21291,7297,31632
产品类型：细胞因子添加物
品牌：PeproTech
| 产品详情产品编号：120-06产品描述：TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity, and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines, however, its function in promoting breast cancer development is unknown. The mature and functional form of BMP-6 is a homodimer of two identical 139 amino acid polypeptide chains linked by a single disulfide bond. Each monomer is expressed as the C-terminal part of a precursor polypeptide, which contains a 20 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.Source:HEK293 cellsSynonyms:Bone Morphogenetic Protein-6, VGR, VG-1-related proteinAA Sequence (monomer):VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCHPurity:≥ 95% by SDS-PAGE gel and HPLC analyses.Biological Activity:Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expectedED50this effect is 0.03-0.06 μg/ml.Calculated Molecular Weight:26.2 kDaAccession Number:P22004Gene ID:654Note:1mg will be provided as 2x500μg.crossreactivity:Human,Human + Mouse,Mouse,RatCountry Of Origin:USANot for human use. |
| product.subtitle.recentcitations |
| 第一作者 | Petzer, V |
| 标题 | A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease. |
| 文献引用 | Blood; 136(9) pg1080-1090PubMed Id |
| PubMed Id | 32438400 |
| 第一作者 | Hall, G N |
| 标题 | Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing |
| 文献引用 | Advanced science (Weinheim, Baden-Wurttemberg, Germany); 7 (2), 1902295PubMed Id |
| PubMed Id | 31993293 |
| 第一作者 | Ikeno, S |
| 标题 | PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling. |
| 文献引用 | The Journal of Biological Chemistry; 294(13) pg4966-4980PubMed Id |
| PubMed Id | 30718277 |
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