货号：04-0079

规格：2 mg

价格：0

产品类型：小分子化合物

品牌：Stemgent

The aminopyrimidinyl carbamate Stemoleculetm WH-4-023 is a potent Src and LCK inhibitor (IC50< 10 nM).¹ WH-4-023 has been shown to support the conversion to and maintenance of human naïve pluirpotent stem cells.²

Stemgent conveniently provides all the components comprising the 5i/L/A media supplment necessary to support naive pluripotent stem cell applications.

5i (inhibitors):

PD0325901 (04-0006),

Y27632 (04-0012),

WH-4-023 (04-0079),

SB590885 (04-0080),

IM-12 (04-0081) or alternatively,

CHIR99021 (04-0004)

L: LIF, Human Recombinant (03-0016), and

A: Activin A, Human Recombinant (03-0001)

1. Martin MW, Newcomb J, Nunes JJ, McGowan DC, Armistead DM, Boucher C, Buchanan JL, Buckner W, Chai L, Elbaum D, Epstein LF, Faust T, Flynn S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Lee JH, Metz D, Middleton S, Mohn D, Morgenstern K, Morrison MJ, Novak PM, Oliveira-dos-Santos A, Powers D, Rose P, Schneider S, Sell S, Tudor Y, Turci SM, Welcher AA, White RD, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Amouzegh P, Ermann M, Jenkins J, Johnston D, Napier S, Power E. “Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.” J. Med Chem. 49(16):4981-91 (2006).

2. Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D’Alessio A, Zhang J, Gao Q, Dawlaty MM, Young RA, Gray NS, Jaenisch R. “Systematic identification of culture conditions for induction and maintenance of naïve human pluripotency.” Cell Stem Cell 15(4):471-87 (2014).