货号：04-0074

规格：2 mg

价格：0

产品类型：小分子化合物

品牌：Stemgent

LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC₅₀= 5 nM and 30 nM respectively)¹. LDN-193189 was derived from structure-activity relationship studies of Dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation^1-3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7¹. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms^4,5. LDN-193189 has been used to reduce ectopic ossification in a mouse model offibrodysplasia ossificans progressiva¹. Stemolecule LDN-193189 is a hydrochloride salt.

产品详情

1. Yu, P.B., Deng, D.Y., Lai, C.S., Hong, C.C., Cuny, G.D., Bouxsein, M.L., Hong, D.W., McManus, P.M., Katagiri, T., Sachidanandan, C., Kamiya, N., Fukuda, T., Mishina, Y., Peterson, R.T., and Bloch, K.D. (2008) BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med 14: 1363-1369.

2. Yu, P.B., Hong, C.C., Sachidanandan, C., Babitt, J.L., Deng, D.Y., Hoyng, S.A., Lin, H.Y., Bloch, K.D., and Peterson, R.T. (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4: 33-41.

3. Cuny, G.D., Yu, P.B., Laha, J.K., Xing, X., Liu, J.F., Lai, C.S., Deng, D.Y., Sachidanandan, C., Bloch, K.D., and Peterson, R.T. (2008) Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett 18: 4388-4392.

4. Heisenberg, C.P., and Solnica-Krezel, L. (2008) Back and forth between cell fate specification and movement during vertebrate gastrulation. Curr Opin Genet Dev 18: 311-316.

5. Cain, J.E., Hartwig, S., Bertram, J.F., and Rosenblum, N.D. (2008) Bone morphogenetic protein signaling in the developing kidney: present and future. Differentiation 76: 831-842.