Mitomycin C from Streptomyces caespitosus/丝裂霉素 C (来源于头状链霉菌)
货号：M7949
规格：Mitomycin C is soluble in DMSO at 1.0 mg/mL
价格：0
产品类型：抗生素和支原体预防
品牌：Sigma
Application
Mitomycin C is produced by a strain of actinomyces,Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.
Biochem/physiol Actions
DNA 合成、细胞核分裂和癌细胞的抑制剂。对革兰氏阳性菌、革兰氏阴性菌、抗酸杆菌有抗菌性。
Caution
This vial contains 2 mg Mitomycin C and 48 mg NaCl. Stock solutions should be filter sterilized and stored at 2-8°C in the dark. Solutions at pH 6-9 can be stored at 0-5°C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.
Preparation Note
Mitomycin C is soluble in DMSO at 1.0 mg/mL
性质
| InChI Key | NWIBSHFKIJFRCO-WUDYKRTCSA-N |
| sterility | γ-irradiated |
| assay | ≥98% (HPLC) |
| form | powder or crystals |
| potency | ≥970μg per mg (USP XXIV) |
| solubility | DMSO: soluble1.0mg/mL |
| suitability | suitable for cell culture |
| Mode of action | DNA synthesis | interferes |
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria |
| neoplastics |
安全信息
| 符号 | GHS06, GHS08 |
| 信号词 | Danger |
| 危害声明 | H300-H351 |
| 警示性声明 | P264-P281-P301 + P310 |
| 危害码 (欧洲) | T |
| 风险声明 (欧洲) | 25-40 |
| 安全声明 (欧洲) | 28-36/37-45 |
| RIDADR | UN 3462 6.1 / PGII |
| WGK德国 | 3 |
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