Recombinant Human PDGF-AB
货号：100-00AB-10,100-00AB-100,100-00AB-1000,100-00AB-2,100-00AB-250,100-00AB-50,100-00AB-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格：1560,9144,36565,640,15974,5475,23727
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of oneα chain and oneβ chain (234 total amino acids).来源:E.coli别名:Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF), PCGF氨基酸序列:Alpha chain:SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPTBeta chain:SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.Calculated Molecular Weight:26.4 kDaAccession Number:Alpha:P04085Beta:P01127Gene ID:Alpha:5154Beta:5155交叉反应:Human,Monkey,Mouse |
product.subtitle.recentcitations |
第一作者 | Geuder, J |
标题 | A non-invasive method to generate induced pluripotent stem cells from primate urine |
文献引用 | Scientific Reports; 11(1) pg3516 |
PubMed Id | 33568724 |
第一作者 | Gillies, T E |
标题 | Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway |
文献引用 | Molecular Systems Biology; 16(10) pge9518 |
PubMed Id | 33073539 |
第一作者 | Wei, D |
标题 | RAB31 marks and controls an ESCRT-independent exosome pathway |
文献引用 | Cell Research; 31(2) pg157-177 |
PubMed Id | 32958903 |
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