Recombinant Human PDGF-CC
货号：100-00CC-100,100-00CC-1000,100-00CC-20,100-00CC-250,100-00CC-5,100-00CC-500
规格：100ug,1mg,20ug,250ug,5ug,500ug
价格：7016,28131,1560,12277,640,18247
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel, disulfide-linked dimer of two 12-14 kDa, polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules' epithelial cell development. Mature PDGFs are stored in platelet α-granules, and are released upon platelet activation. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGFR-α receptor, whereas PDGF-DD interacts almost exclusively with the PDGFR-β receptor. Recombinant Human PDGF-CC is a 25.0 kDa protein consisting of two identical disulfide-linked, 112 amino acid, polypeptide chains.来源:E.coli别名:Platelet-Derived Growth Factor-CC氨基酸序列 (monomer):MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected TheED50for this effect is 15-20 ng/ml.Calculated Molecular Weight:25 kDaAccession Number:Q9NRA1Gene ID:56034Note:250μg is the largest vial size for this product.Larger sizes supplied as multiple 250μg vials.交叉反应:Human,Mouse |
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