Recombinant Human IGF-I LR3
货号：100-11R3-200,100-11R3-1000
规格：200µg,1mg
价格：640,1560
产品类型：细胞因子添加物
品牌：PeproTech
| 别名:Long R3 IGF-I, Insulin-like Growth Factor-I, Somatamedin C, IGF-IA描述:The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissuein vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. IGF-I LR3 is a recombinant analog of human IGF-I comprised of the complete IGF-I sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension. Specifically engineered for higher biological potencyin vitro, IGF-I LR3 has an increased half-life and a binding aversion to native proteins within the body that make it ideal for both research and large-scale culturing. Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues.氨基酸序列:MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA来源:E.coli纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105units/mg.Calculated Molecular Weight:9.1 kDaAccession Number:P05019Gene ID:3479交叉反应:Human原产地: USA仅用于研究。不适用于诊断或治疗。 |
product.subtitle.recentcitations |
第一作者 | Sharma, P |
标题 | Exosomes regulate neurogenesis and circuit assembly. |
文献引用 | Proceedings of the National Academy of Sciences of the United States of America; 116(32) pg16086-16094 |
PubMed Id | 31320591 |
第一作者 | Carrió, M |
标题 | Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas. |
文献引用 | Stem Cell Reports; 12(2) pg411-426 |
PubMed Id | 30713041 |
第一作者 | Wu, J |
标题 | Interspecies Chimerism with Mammalian Pluripotent Stem Cells. |
文献引用 | Cell; 168(3) pg473-486.e15 |
PubMed Id | 28129541 |
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