Animal-Free Recombinant Human TGF-β3
货号：AF-100-36E-2,AF-100-36E-10,AF-100-36E-50,AF-100-36E-250,AF-100-36E-100,AF-100-36E-1000,AF-100-36E-500
规格：2µg,10µg,50µg,250µg,100µg,1mg,500µg
价格：791,1778,8304,23339,13830,53444,34670
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of oneα chain and oneβ chain (234 total amino acids).来源:E.coli别名:Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF), PCGF氨基酸序列:Alpha chain:SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPTBeta chain:SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.Calculated Molecular Weight:26.4 kDaAccession Number:Alpha:P04085Beta:P01127Gene ID:Alpha:5154Beta:5155交叉反应:Human,Monkey,Mouse |
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