Animal-Free Recombinant Human IGF-II
货号：AF-100-12-10,AF-100-12-100,AF-100-12-1000,AF-100-12-50,AF-100-12-500
规格：10µg,100ug,1mg,50ug,500ug
价格：795,4020,15545,1787,10081
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissuein vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-II is 7.5 kDa.Manufactured using all Animal-Free reagents.来源:E.coli别名:Insulin-like Growth Factor-II, Somatamedin A氨基酸序列:AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to stimulate the proliferation of mouse FDC-P1 cells. The expectedED50is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105units/mg.Calculated Molecular Weight:7.5 kDaAccession Number:P01344Gene ID:3481 |
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