Recombinant Human IL-12 p70 (CHO derived)
货号:200-12-10,200-12-100,200-12-1000,200-12-2,200-12-250,200-12-50,200-12-500
规格:10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格:1418,11263,44326,582,19355,6634,28757
产品类型:细胞因子添加物
品牌:PeproTech
产品描述:IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).来源:CHO cells别名:Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSFp35:Interleukin-12 subunit alpha, IL-12 subunit p35, IL-12A, Cytotoxic Lymphocyte Maturation Factor 35 kDa subunit (CLMF p35), NK cell Stimulating Factor Chain 1p40:Interleukin-12 subunit beta, IL-12 subunit p40, IL-12B, CytotoxicLymphocyte Maturation Factor 40 kDa subunit (CLMF p40), NK cell Stimulating Factor Chain 2氨基酸序列:p35 Subunit:RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNASp40 Subunit:IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Assay #1:Determined by its ability to induce IFN-γ production from NK cells co-stimulated with IL-18. The expectedED50is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.Assay #2:Determined by its ability to increase IFN-γ production by anti-TCR mAb-stimulated PBMCs. The expectedED50for this effect is 4.0-8.0 ng/ml.Calculated Molecular Weight:75 kDaAccession Number:p35:P29459p40:P29460Gene ID:p35:3592p40:3593交叉反应:Bacteria,Human,Human + Hamster,Human + Mouse,Monkey,Mouse原产国:USA |
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