Recombinant Human sOX40 Ligand
货号：310-28-10,310-28-100,310-28-1000,310-28-2,310-28-250,310-28-500
规格：10ug,100ug,1mg,2ug,250ug,500ug
价格：1418,11069,44326,582,19355,28757
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between “friend vs. foe” during activation; a mechanism typically termed immuno-tolerance. Recombinant Human sOX40 Ligand is a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5 – 25.0 kDa on SDS-PAGE.来源:Hi-5 Insect cells别名:TNFSF4, OX40L, Gp34, CD252氨基酸序列:QVSHRYPRIQ SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF CVL纯度:≥ 97% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml.Note: Results may vary with PBMC donors.Calculated Molecular Weight:15.4 kDaAccession Number:P23510Gene ID:7292交叉反应：Human原产国:USA |
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