Anti-Mouse CD335 (NKp46) Purified

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Anti-Mouse CD335 (NKp46) Purified

货号:37412-20-50,37412-20-500

规格:50 μg,500 μg

价格:1100,3630

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :37412-20

Description

The 29A1.4 antibody specifically reacts with CD335 (NKp46), a 46kDA natural cytotoxicity receptor family molecule. It is expressed in only NK and a rare subset of NK-like T cells, not including the CD1d-restricted NKT division. CD335 is active during NK lysis of pathogen-infected and tumor cells.

The 29A1.4 in vitro activates NK cells, but does not deplete NK cells in vivo.

Additional Information

Clone

29A1.4

Format:

Purified

Applications

FC, IHC

Reactivity

Mouse

Isotype:

Rat IgG2b, kappa

Research Interest:Innate Immunity
Cell Type:NK and NKT Cells

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Walzer, T., Bléry, M., Chaix, J., Fuseri, N., Chasson, L., Robbins, S. H., ... & Vivier, E. (2007). Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46.Proceedings of the National Academy of Sciences,104(9), 3384-3389.

Joncker, N. T., Fernandez, N. C., Treiner, E., Vivier, E., & Raulet, D. H. (2009). NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model.The Journal of Immunology,182(8), 4572-4580.

Gazit, R., Gruda, R., Elboim, M., Arnon, T. I., Katz, G., Achdout, H., ... & Mandelboim, O. (2006). Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1.Nature immunology,7(5), 517-523.

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