Clone

4H1

Format:

FITC

Applications

FC

Reactivity

Human

Isotype:

Mouse IgG1, kappa

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Woodcock, J. M., McClure, B. J., Stomski, F. C., Elliott, M. J., Bagley, C. J., & Lopez, A. F. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF, interleukin-3, or interleukin-5.Blood,90(8), 3005-3017.

Lopez, A. F., Vadas, M. A., Woodcock, J. M., Milton, S. E., Lewis, A., Elliott, M. J., ... & Park, L. S. (1991). Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils.Journal of Biological Chemistry,266(36), 24741-24747.

Guthridge, M. A., Barry, E. F., Felquer, F. A., McClure, B. J., Stomski, F. C., Ramshaw, H., & Lopez, A. F. (2004). The phosphoserine-585–dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2.Blood,103(3), 820-827.