Anti-Human CD180 (RP-105) SAFIRE Purified

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Anti-Human CD180 (RP-105) SAFIRE Purified

货号:12911-25

规格:100 ug

价格:2805

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :12911-25

Description

The MHR73-11 monoclonal antibody binds to human CD180, a 105kDA cell surface molecule consisting of extracellular leucine rich repeats (LCC) and a short cytoplasmic tail also known as Bgp-95 and RP105. CD180 is expressed on B cells, dendritic cells, monocytes, and macrophages. It forms a cell surface receptor complex with MD-1 and with TLR4 is involved with the recognition of bacterial lipopolysaccharide (LPS). The MHR73-11 antibody is reported to protect against dexamethasone and irradiation induced apoptosis in B cells.

Additional Information

Clone

MHR73-11

Format:

SAFIRE Purified

Applications

FC, FA

Reactivity

Human

Isotype:

Mouse IgG1, kappa

Research Interest:Innate Immunity,Apoptosis
Cell Type:B Cells,Dendritic Cells,Monocytes and Macrophages

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Miura, Y., Shimazu, R., Miyake, K., Akashi, S., Ogata, H., Yamashita, Y., ... & Kimoto, M. (1998). RP105 is associated with MD-1 and transmits an activation signal in human B cells.Blood,92(8), 2815-2822.

Miguet, L., Lennon, S., Baseggio, L., Traverse-Glehen, A., Berger, F., Perrusson, N., ... & Mauvieux, L. (2013). Cell-surface expression of the TLR homolog CD180 in circulating cells from splenic and nodal marginal zone lymphomas.Leukemia,27(8), 1748-1750.

Koarada, S., Tada, Y., Sohma, Y., Haruta, Y., Suematsu, R., Mitamura, M., ... & Nagasawa, K. (2010). Autoantibody-producing RP105− B cells, from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with BAFF-R than normal subjects.Rheumatology,49(4), 662-670.

技术参数
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