Anti-Human CD49d APC

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Anti-Human CD49d APC

货号:11511-80-25,11511-80-100

规格:25 tests,100 tests

价格:1540,3245

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalog Number :11511-80

Description

The 9F10 monoclonal antibody specifically reacts with human CD49d, the 150 kDA alpha 4 integrin chain. The molecule forms the heterodimer called VLA-4 with integrin beta 1 and another heterodimer with integrin beta 7 that binds fibronectin, VCAM-1, and MadCAM-1. CD49d is expressed on monocytes, lymphocytes, thymocytes, NK cells, B cells, and T cells. It is involved in hematopoietic stem cell differentiation, cell migration, and cell activation. Its absence on Foxp3+ cells make it a useful marker to isolate Treg cell populations.

Additional Information

Clone

9F10

Format:

APC

Applications

FC

Reactivity

Human

Isotype:

Mouse IgG1, kappa

Research Interest:Adaptive Immunity,Angiogenesis
Cell Type:B Cells,Monocytes and Macrophages,T Cells,Dendritic Cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Schlossman, S. F. (1995).Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Kleinewietfeld, M., Starke, M., Di Mitri, D., Borsellino, G., Battistini, L., Rötzschke, O., & Falk, K. (2009). CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells.Blood,113(4), 827-836.

Hemler, M. E. (1990). VLA proteins in the integrin family: structures, functions, and their role on leukocytes.Annual review of immunology,8(1), 365-400.

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