CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), APC

货号：17-5971-82,17-5971-63,17-5971-81

规格：100 μg,10μg,50μg

价格：2987,0,1442

产品类型：流式抗体

品牌：Thermo Fisher

物种：小鼠

宿主：大鼠

抗体亚型：IgG

克隆号：DX5

荧光染料：APC

抗体类型:	单抗	同型对照：	Rat IgM Isotype Control, APC, eBioscience™
免疫原性：		用法：	1 µg/test(Flow）

Description: The DX5 monoclonal antibody reacts with CD49b, an antigen expressed on a majority of mouse natural killer cells and a subset of T cells. DX5 reacts with all strains of mouse tested including the most commonly used strains, BALB/c, C57BL/6, C3H, CBA, DBA, AKR, SJL and 129. Simultaneous staining of C57BL/6 spleen cells with anti-NK1.1 mAb (PK136) and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells.Applications Reported: The DX5 antibody has been reported for use in flow cytometric analysis.Applications Tested: The DX5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationGTP-binding proteins (G-proteins) play a critical role in signal transduction by coupling receptors to effectors. The intracellular consequences of G-protein activation include second messenger generation, protein phosphorylation, ion channel activation, gene induction, cell growth, and differentiation. Gi belongs to the pertussis toxin sensitive G-proteins. Gi consists of three different subtypes of a-subunits (ai1, ai2 and ai3).For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

CD49b (Integrin alpha 2) Antibody (17-5971-82) in Flow Staining of C57Bl/6 splenocytes with Anti-Mouse NK1-1 FITC (Product # 11-5941-82) and 0.5 µg of Rat IgM Isotype Control APC (Product # 17-4341-82) (left) or 0.5 µg of Anti-Mouse CD49b (Integrin alpha 2) APC (right). Cells in the lymphocyte gate were used for analysis.

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参考文献：

1. JCI insightsignaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia."17-5971 was used in Magnetic cell separation to determine factors regulating the pathogenic mechanisms of biliary atresia."AuthorsShivakumar P,Mizuochi T,Mourya R,Gutta S,Yang L,Luo Z,Bezerra JA2. Cellular and molecular immunologyThe breast tumor microenvironment alters the phenotype and function of natural killer cells.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer3. Molecular therapy oncolyticsIntratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer."17-5971 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy."AuthorsKober C,Weibel S,Rohn S,Kirscher L,Szalay AA4. PloS oneExpression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice."17-5971 was used in Flow cytometry/Cell sorting to generate a mouse model expressing chimeric antigen receptors (CARs) specific for a tumour antigen under a pan-hematopoietic promoter."AuthorsYong CS,Westwood JA,Schröder J,Papenfuss AT,von Scheidt B,Moeller M,Devaud C,Darcy PK,Kershaw MH5. PloS oneNatural killer cells promote long-term hepatobiliary inflammation in a low-dose rotavirus model of experimental biliary atresia."17-5971 was used in Flow cytometry/Cell sorting to investigate mechanisms of liver injury in a mouse model of Rhesus rotavirus-induced biliary atresia."AuthorsSquires JE,Shivakumar P,Mourya R,Bessho K,Walters S,Bezerra JA

技术参数

产品应用 Flow

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