Anti-Human CD25 Antibody, Clone 2A3

货号：60153PE

规格：50 tests

价格：10094

产品类型：流式抗体

品牌：STEMCELL Technologies

物种：人

宿主：仓鼠

抗体亚型：IgG

荧光染料：Purified

The 2A3 antibody reacts with human CD25, a 55 kDa type I integral transmembrane glycoprotein also known as low-affinity interleukin-2 receptor alpha chain (IL-2Rα) or Tac antigen. CD25 is present on activated T and B cells, monocytes, macrophages, and regulatory T cells. CD25 has role in T-lymphocyte activations and identification of T-cell subsets in viral infections like HIV and HTLV. CD25 associates with IL-2 receptor β (CD122) and common γ (CD132) chains to form a high affinity IL-2R complex. The 2A3 antibody binds to an epitope on p55 at or near the IL-2 binding site and prevents high-affinity IL-2 binding to T lymphocytes. Daclizumab, a therapeutic humanised monoclonal antibody, blocks the binding of 2A3 antibody.

技术参数

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