All-Trans Retinoic Acid

货号：72262

规格：50mg

价格：748

产品类型：小分子化合物

品牌：STEMCELL Technologies

All-Trans Retinoic Acid is a derivative of Vitamin A that functions as a ligand for the retinoic acid receptor (RAR, IC₅₀ = 14 nM). RARs heterodimerize with retinoid X receptors (RXRs) and bind to retinoic acid response elements (RAREs) in DNA and act as transcription factors, altering gene expression. (Apfel et al., Chambon)DIFFERENTIATION· Promotes differentiation of motor neurons from mouse and human pluripotent stem cells (Dimos et al., Wichterle et al.).· Promotes differentiation of neurons from neural stem cells (Takahashi et al.).· Promotes differentiation of pancreatic progenitors from human embryonic stem (ES) cells (D'Amour et al.).· Promotes differentiation of adipocytes from mouse ES cells (Dani et al.).· Promotes differentiation of ventricular cardiomyocytes from mouse ES cells (Wobus et al.).· Promotes terminal differentiation of granulocytes (Collins).CANCER RESEARCH· Promotes maturation of blast cells in differentiation therapy of acute promyelocytic leukemia (Huang et al.).

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