P-cadherin Monoclonal Antibody (12H6), Alexa Fluor 555

货号： MA3-24000-A555

规格：50 µl

价格：4223

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：其它

荧光染料：Alexa Fluor 555

类型:	单抗	同型对照：	IgG1
免疫原性：	Human P-Cadherin fusion protein	用法：	1-10 µg/mL(ICC);1-10 µg/mL(IF)

Target InformationP-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

P-cadherin Antibody (MA3-24000-A555) in IFImmunofluorescent analysis of p-Cadherin (orange) in A431 cells. The cells were permeabilized with 0.1% Triton X-100 in TBS for 15 minutes, and blocked with 3% Blocker BSA in PBS (Product # 37525) for 30 minutes at room temperature. Cells were stained with a p-Cadherin mouse monoclonal antibody, AlexaFluor 555 conjugate (Product # MA3-24000-A555), at a concentration of 10 µg/mL in blocking buffer for at least 1 hour at room temperature protected from light. Nuclei (blue) were stained with Hoechst 33342 dye (Product # 62249) at a dilution of 1:10,000 in blocking buffer. Images were taken on a Thermo Scientific ToxInsight Instrument at 20X magnification.

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