SOX2 Polyclonal Antibody

货号：PA1-16968

规格：100 µL

价格：5770

产品类型：流式抗体

品牌：Thermo Fisher

物种：人/小鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

类型:	多抗	同型对照：	IgG
免疫原性：	Synthetic peptide made to the N-terminal region of human SOX2 protein (within residues 1-100). [Swiss-Prot# P48431]	用法：	1:100(Flow);1:50-1:250(ICC);1:50-1:250(IF);0.5 µg/mL(WB)

Product Specific InformationThe target sequence has 92% sequence homology with chicken, 86% sequence homology with xenopus, and 71% sequence homology with zebrafish.Suggested positive control: antigen standard for SOX2 (transient overexpression lysate), mouse brain lysate, mouse brain protein, uterual endometrial glands.Target InformationSOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

SOX2 Antibody (PA1-16968) in ICCICC staining of NTera2 cells using Product # PA1-16968 for SOX2 (Green) at a 1:50 dilution and an anti-alpha-Tubulin (Red) at a 1:1000 dilution. Nuclei (Blue) were counterstained using Hoechst 33258. SOX2 Antibody (PA1-16968) in FlowFACS staining of NTERA-2 cells using Product # PA1-16968 at a 1:50 dilution detected using Dylight-488 conjugated goat anti-rabbit IgG secondary antibody. SOX2 Antibody (PA1-16968) in IHCImmunohistochemical staining of uterus, endometrial glands using Product # PA1-16968.

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参考文献：

1.Nature communicationsDynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment.2.Stem cell research and therapyComprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.3.PloS oneSETD7 Regulates the Differentiation of Human Embryonic Stem Cells. 4.Tissue engineering. Part AExpansion and differentiation of germline-derived pluripotent stem cells on biomaterials."PA1-16968 was used in immunocytochemistry to study biomaterials that maintain self-renewal and differentiation potential and those that promote the differentiation of germline-derived pluripotent stem cells"AuthorsHoss M,Šarić T,Denecke B,Peinkofer G,Bovi M,Groll J,Ko K,Salber J,Halbach M,Schöler HR,Zenke M,Neuss S

技术参数

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