LIN28A Monoclonal Antibody (GT1086)

货号：MA5-31462

规格：100 µL

价格：4806

产品类型：流式抗体

品牌：Thermo Fisher

抗原：LIN28A

物种：人

宿主：小鼠

抗体亚型：其它

克隆号：GT1086

荧光染料：Purified

类型:	单抗	同型对照：	IgG2b
免疫原性：	Recombinant protein encompassing a sequence within the center region of human LIN28.	用法：	1:50(Flow);1:100-1:1000(ICC);1:100-1:1000(IF);1:100-1:1000(IHC (P));1:500-1:3000(WB)

Product Specific InformationKeep as concentrated solution.Positive Control: NT2D1, human ESC, LIN28 transfected HeLa lysates.Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Target InformationLin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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