ABCA4 Monoclonal Antibody (3F4)
货号：MA5-33095
规格：100 µL
价格：5816
产品类型：免疫组化一抗
品牌：eBioscience
物种：人/小鼠
宿主：小鼠
抗体亚型：IgG
荧光染料：Purified
类型: | 单抗 | 同型对照： | |
浓度： | 1 mg/mL | 用法： | Assay-Dependent（IHC ）；Assay-Dependent(WB) |
免疫原性： | Partially purified bovine 220-kDa disc rim protein | | |
产品详细信息Excitation: 405 nm; Emission: 645 nm; Laser: Blue Laser靶标信息ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.
数据 |
| ABCA4 Antibody (MA5-33095) in IHCImmunohistochemical analysis of ABCA4 in adult mouse retina using a Polyclonal antibody (Product # MA5-33095). immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA. |
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