SOX1 Polyclonal Antibody

货号：PA5-95248

规格：100 µg

价格：4732

产品类型：免疫组化一抗

品牌：eBioscience

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

类型:	多抗	同型对照：
浓度：		用法：	0.1-0.5 µg/mL (WB)
免疫原性：	A synthetic peptide corresponding to a sequence in the middle region of Human SOX1, identical to the related mouse sequence.

产品详细信息Synthetic peptide sequence: 215-248aa, QHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHR.Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 ug/mL.靶标信息SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.

数据

SOX1 Antibody (PA5-95248) in WB Western blot analysis of SOX1 in Lane 1: rat brain tissue lysate (50 µg), Lane 2: NIH3T3 whole cell lysate (40 µg). Samples were incubated with SOX1 polyclonal antibody (Product # PA5-95248).

二抗荧光二抗免疫组化一抗标签抗体

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技术参数

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