SOX1 Recombinant Rabbit Monoclonal Antibody (JJ20-40)
货号：MA5-32447
规格：100 µL
价格：4732
产品类型：免疫组化一抗
品牌：eBioscience
物种：人/小鼠
宿主：兔
抗体亚型：IgG
荧光染料：Purified
类型: | 单抗 | 同型对照： | |
浓度： | 1 mg/mL | 用法： | 1:50-1:100 (ICC)；1:50-1:100 (IF)；1:50-1:100（IHC）；1:500-1:1000 (WB) |
免疫原性： | Human SOX1 aa 100-20 |
产品详细信息Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. 靶标信息SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
数据 |
| SOX1 Antibody (MA5-32447) in ICC Immunocytochemical analysis of SOX1 in SHG-44 cells using a SOX1 Monoclonal antibody (Product # MA5-32447) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
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| 二抗荧光二抗免疫组化一抗标签抗体 |
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