Recombinant Human/Murine/Rat Activin A (Insect derived)
货号：120-14-2,120-14-10,120-14-50,120-14-100,120-14-250,120-14-500,120-14-1000
规格：2µg,10µg,50 µg,100 µg,250 µg,500 µg,1 mg
价格：1050,2570,9000,15010,26270,39030,60060
产品类型：细胞因子添加物
品牌：PeproTech
| 产品详情产品编号：120-14产品描述：Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.Source:Hi-5 Insect cellsSynonyms:Inhibin beta-1, FRP, FSH (Follicle-Stimulating Hormone)-releasing protein, Erythroid Differentiation Factor (EDF)AA Sequence (monomer):GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCSPurity:≥ 95% by SDS-PAGE gel and HPLC analyses.Biological Activity:Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expectedED50is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105units/mg.Calculated Molecular Weight:26 kDaAccession Number:P08476Gene ID:3624Note:1mg will be provided as 2x500μg.crossreactivity:Chicken,Dog,Frog,Human,Human + Mouse,Mouse,RatCountry Of Origin:USANot for human use. |
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