Recombinant Human Heregulinβ-1
货号：100-03-10,100-03-50,100-03-100,100-03-250 ,100-03-500,100-03-1000
规格：10µg,50µg,100µg,250µg,500µg,1mg
价格：582,1418,3187,5581,8292,12787
产品类型：细胞因子添加物
品牌：PeproTech
| 描述：Neuregulin/Heregulin is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant Human Heregulinβ-1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues). 来源:E.coli氨基酸序列：SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106units/mg.交叉反应:Human , Mouse, Rat |
product.subtitle.recentcitations |
第一作者 | Goranci-Buzhala, G |
标题 | Cilium induction triggers differentiation of glioma stem cells. |
文献引用 | Cell Reports; 36(10) pg109656 |
PubMed Id | 34496239 |
第一作者 | Parent, A V |
标题 | Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. |
文献引用 | Cell Reports; 36(7) pg109538 |
PubMed Id | 34407395 |
第一作者 | Ebisudani, T |
标题 | Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening. |
文献引用 | Cell Reports; 35(10) pg109218 |
PubMed Id | 34038715 |
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