TNFRSF6B (DcR3) Human ELISA Kit/人TNFRSF6B (DcR3) ELISA试剂盒
货号：EHTNFRSF6B,EHTNFRSF6BX5,EHTNFRSF6BX10
规格：96 tests,5X96 tests,10X96 tests
价格：7238,29891,52892
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.3 ng/mL |
| 检测范围 | 0.328-80 ng/mL |
样本类型/体积 | 上清液 100 μL 血清 50 μL 血浆 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 分析稀释浓缩液 - 生物素化检测抗体 -SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | DcR3 |
| Protein aliases | DcR3, Decoy receptor 3, decoy receptor 3 variant 1, decoy receptor 3 variant 2, Decoy receptor for Fas ligand, M68, Tumor necrosis factor receptor superfamily member 6B, tumor necrosis factor receptor superfamily member 6b, decoy, tumor necrosis factor receptor superfamily, member 6b |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | DCR3, DJ583P15.1.1, M68, M68E, TNFRSF6B, TR6, UNQ186/PRO212 |
| Gene ID | (Human) 8771 |
| Gene symbol | TNFRSF6B |
| UniProt ID | (Human) O95407 |
| The Human TNFRSF6B (DcR3) ELISA quantitates Hu DcR3 in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu DcR3.人TNFRSF6B（DcR3）ELISA定量了人血清，血浆或细胞培养基中的人DcR3。 该检测试剂盒将只识别天然和重组人DcR3。Principle of the method 方法原理The Human DcR3 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.人DcR3固相夹心ELISA（酶联免疫吸附测定）设计用于测量匹配的抗体对之间结合的靶标量。 已在提供的微孔板的孔中预包被了靶标特异性抗体。 然后将样品，标准液或质控品添加到这些孔中，并与固定的（捕获）抗体结合。 通过添加第二（检测）抗体形成三明治，添加底物溶液，该底物溶液与酶-抗体-靶标复合物反应以产生可测量的信号。 该信号的强度与原始样品中存在的靶标浓度成正比。Rigorous validation 严格验证Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.此ELISA试剂盒的每个制造批次均经过质量测试，其标准包括敏感性，特异性，精密度和批次间一致性。 有关验证的更多信息，请参见手册。Target information 靶标信息Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.细胞凋亡是由某些细胞因子（包括TNF家族中的TNF和Fas配体）通过其包含死亡域的受体诱导的。 最近发现了TNFR家族中的几个新成员，包括DR3，DR4，DR5和DR6，它们可作为细胞死亡受体。 最近发现，两个诱饵受体DcR1和DcR2与DR4和DR5竞争配体TRAIL结合。 最近发现了一种新型诱饵受体，分别命名为DcR3和TR6。 与DcR1和DcR2不同，DcR3是可溶的而不是膜相关的分子。 DcR3与FasL和LIGHT结合并抑制FasL和LIGHT诱导的细胞凋亡。 DcR3转录本在许多肺癌和结肠癌以及某些正常组织中表达。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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