BMP-2 Human ELISA Kit/人BMP-2 ELISA试剂盒
货号：EHBMP2,EHBMP2X5,EHBMP2X10
规格：96 tests,5X96 tests,10X96 tests
价格：7238,29891,52892
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 45 pg/mL |
| 检测范围 | 46.88-3000 pg/mL |
样本类型/体积 | 上清液 100 μL 血清 50 μL 血浆 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 分析稀释浓缩液 - 生物素化检测抗体 -SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | BMP-2 |
| Protein aliases | BMP-2, Bone morphogenetic protein 2A, BMP-2A, Bone morphogenetic protein 2 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | BDA2, BMP2, BMP2A |
| Gene ID | (Human) 650 |
| Gene symbol | BMP2 |
| UniProt ID | (Human) P12643 |
| The Human Bone Morphogenic Protein 2 (Hu BMP-2) ELISA quantitates Hu BMP-2 in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu BMP-2.人骨形态发生蛋白2（Hu BMP-2）ELISA定量了人血清，血浆或细胞培养基中的Hu BMP-2。 该检测试剂盒将专门识别天然和重组Hu BMP-2。Principle of the method 方法原理The Human BMP-2 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.人BMP-2固相夹心ELISA（酶联免疫吸附测定）设计用于测量匹配的抗体对之间结合的靶标量。 已在提供的微孔板的孔中预包被了靶标特异性抗体。 然后将样品，标准液或质控品添加到这些孔中，并与固定的（捕获）抗体结合。 通过添加第二（检测）抗体形成三明治，添加底物溶液，该底物溶液与酶-抗体-靶标复合物反应以产生可测量的信号。 该信号的强度与原始样品中存在的靶标浓度成正比。Rigorous validation 严格验证Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.此ELISA试剂盒的每个制造批次均经过质量测试，其标准包括敏感性，特异性，精密度和批次间一致性。 有关验证的更多信息，请参见手册。Target information 靶标信息Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).骨形态发生蛋白（BMP）是影响骨骼和软骨形成的TGF-β超家族成员（Hogan 1996，Reddi 1998和Francis-West等1999）。 成熟的BMP是30-38 kDa的蛋白质，具有TGF-β样半胱氨酸结构型。 洛伐他汀通过打开bmp-2基因来增加骨形成（Mundy等，1999）。 BMP刺激特定骨基质蛋白的产生，并改变基质细胞和破骨细胞增殖（Macias等，1999； Lecanda等，1997）。 BMPs也可能是内脏发育的重要因素，在细胞增殖，凋亡，分化和形态发生中起作用（Hogan 1996，Dale and Wardle 1999）。 BMP似乎负责正常的背/腹模式。 像TGF-β一样，BMPs结合II型受体，然后募集转导的I型受体单元，激活Smad蛋白信号传导途径（Massague 1994，Derynck 1997，Attisano 1993）。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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