CD81 Monoclonal Antibody (M38)/CD81单抗 (M38)
货号：MA1-10290
规格：100 µg
价格：3740
产品类型：流式抗体
品牌：Thermo Fisher
抗原：MOLT-4 (human T-ALL cell line)
物种：人
宿主：小鼠
抗体亚型：IgG
克隆号：M38
荧光染料：其它
| 类型: | 单抗 | 同型对照： | IgG1 |
| 浓度： | 1 mg/mL | 用法： | 1 µg/mL(Flow);Assay Dependent(ICC;IP;WB) |
靶标信息CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.
数据 |
| CD81 Antibody (MA1-10290)Nature communications 2018 - Fig. 1 Characterization of exosomes from HIV-infected T cells. a Transmission electron microscope (TEM) images of exosomes isolated from T-cell culture supernatants. The representative J1.1 cell exosome image is shown. Scale bar, 100 nm. b Immunoblot of CD63, CD9, and CD81 on proteins extracted from T-cell line exosomes (whole scans of blots in Supplementary Figure 1). c CD63 and CD9 immunoblot (left) and AChE assays (right) of J1.1 exosomes isolated from 2, 10, and 20 ml of culture supernatants. Error bars, +- s.d. Data shown one experiment from three biological repeats. Numbers of exosomes (#Exo) were calculated by AChE activity using a standard provided by SBI |
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参考文献： |
| 1.Nature communicationsExosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA. |
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