CD29 (Integrin beta 1) Monoclonal Antibody (TS2/16), FITC

货号：11-0299-41,11-0299-42

规格：25 Tests,100 Tests

价格：867,1972

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：小鼠

抗体亚型：IgG

克隆号：TS2/16

荧光染料：FITC

类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC
浓度：	5 µL/Test	用法：	5 μL (0.25 μg)/test(Flow)

产品详细信息Description: The TS2/16 monoclonal antibody reacts with human CD29, also known as integrin beta 1, an approximately 130 kDa single-pass transmembrane glycoprotein. CD29 complexes with one of nine integrin alpha subunits to form the very late antigen (VLA) subfamily of adhesion molecules. Integrin heterodimers containing CD29 are involved in cell-cell and cell-matrix adhesion. CD29 is expressed broadly on lymphocytes and monocytes, with lower levels of expression on granulocytes. The TS2/16 antibody has been found to possess activating activity for beta 1 integrins.Applications Reported: This TS2/16 antibody has been reported for use in flow cytometric analysis.Applications Tested: This TS2/16 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins. ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component ofvarious protein complexes binding to extracellular matrix proteins. Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug. ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue. Further, ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta. More than 8 beta subunits with numerous splice variant isoforms have been identified in mammals. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. The distribution pattern in adult tissues for integrin beta types are mutually exclusive. Beta1A is present in all tissues, except cardiac and skeletal muscle which express the beta1D variant.

数据

CD29 (Integrin beta 1) Antibody (11-0299-41) in FlowStaining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (blue histogram) or Anti-Human CD29 FITC (purple histogram). Cells in the monocyte (left) or lymphocyte (right) gates were used for analysis。

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参考文献：

1.Stem cells internationalAccelerated Wound Healing by Fibroblasts Differentiated from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in a Pressure Ulcer Animal Model."Published figure using CD29 (Integrin beta 1) monoclonal antibody (Product # 11-0299-42) in Flow Cytometry"2.Stem cell research and therapyExosomes secreted by adipose-derived mesenchymal stem cells regulate type I collagen metabolism in fibroblasts from women with stress urinary incontinence."11-0299 was used in Flow cytometry/Cell sorting to evaluate the effects of exomes secreted by adipose-derived mesenchymal stem cells on collagen metabolism in cultured fibroblasts from women with stress urinary incontinence."AuthorsLiu X,Wang S,Wu S,Hao Q,Li Y,Guo Z,Wang W3.Stem cell research and therapyEfficacy of autologous stem cell-based therapy for osteonecrosis of the femoral head in sickle cell disease: a five-year follow-up study."11-0299 was used in Flow cytometry/Cell sorting to report a significant improvement in clinical joint symptoms and pain relief in patients after bone marrow-derived mononuclear cell implantation."AuthorsDaltro GC,Fortuna V,de Souza ES,Salles MM,Carreira AC,Meyer R,Freire SM,Borojevic R4.International journal of clinical and experimental pathologyPDGFR-β (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo."Published figure using CD29 (Integrin beta 1) monoclonal antibody (Product # 11-0299-42) in Flow Cytometry"5.Stem cell research and therapyHuman adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model."11-0299 was used in Flow cytometry/Cell sorting to demonstrate human adipose derived stem cell (hDAC) intervention with MCAO mice could apparently ameliorate stroke symptoms by direct cell replacement, enhanced immnunosuppression and increasing the viability of endogenous neurons."

技术参数

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