CD38 Monoclonal Antibody (90), FITC

货号： 11-0381-81,11-0381-82

规格：50μg,100μg

价格：934,1620

产品类型：流式抗体

品牌：eBioscience

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号： 90

荧光染料：FITC

类型:	单抗	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), FITC
浓度：	0.5 mg/mL	用法：	0.125 μg/test(Flow)

产品详细信息Description: The 90 monoclonal antibody reacts with the mouse CD38 molecule, an ~42 kDa type II transmembrane protein. CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. Its expression is reported on a subpopulation of thymocytes, mature T cells, and NK cells. Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhancedby co-signals such as IL-4 and LPS. CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a role in lymphocyte activation and differentiation.Applications Reported: The 90 antibody has been reported for use in flow cytometric analysis.Applications Tested: The 90 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

数据

CD38 Antibody (11-0381-81) in FlowStaining of mouse splenocytes with 0.06 µg of Rat IgG2a K Isotype Control FITC (Product # 11-4321-42) (blue histogram) or 0.06 µg of Anti-Mouse CD38 FITC (purple histogram). Cells in the lymphocyte gate were used for analysis.

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参考文献：

1.Nature communicationsMolecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25."11-0381 was used in Flow cytometry/Cell sorting to inform on the disposition of Pfs25 on the surface of ookinetes and provide the structural blueprints to design next-generation immunogens."AuthorsScally SW,McLeod B,Bosch A,Miura K,Liang Q,Carroll S,Reponen S,Nguyen N,Giladi E,Rämisch S,Yusibov V,Bradley A,Lemiale F,Schief WR,Emerling D,Kellam P,King CR,Julien JP2.Nature communicationsEZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop."Published figure using CD38 monoclonal antibody (Product # 11-0381-82) in Flow Cytometry"3.Nature communicationsLimited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization."Published figure using CD38 monoclonal antibody (Product # 11-0381-82) in Flow Cytometry"4.PloS oneNovel Markers to Delineate Murine M1 and M2 Macrophages."11-0381 was used in Flow cytometry/Cell sorting to perform a transcriptome analysis of M1 and M2 macrophages and validate candidate phenotype-specific markers."AuthorsJablonski KA,Amici SA,Webb LM,Ruiz-Rosado Jde D,Popovich PG,Partida-Sanchez S,Guerau-de-Arellano M5.PloS oneBILL-cadherin/cadherin-17 contributes to the survival of memory B cells."Published figure using CD38 monoclonal antibody (Product # 11-0381-82) in Flow Cytometry"

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