CD62L (L-Selectin) Monoclonal Antibody (MEL-14), FITC

货号：11-0621-81,11-0621-82,11-0621-85,11-0621-86

规格：50μg,100μg,500μg,1mg

价格：838,1442,3003,4771

产品类型：流式抗体

品牌：eBioscience

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号：MEL-14

荧光染料：FITC

类型:	单抗	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), FITC
浓度：	0.5 mg/mL	用法：	0.5 μg/test(Flow)

产品详细信息Description: The MEL-14 monoclonal antibody reacts with mouse CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCam-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.Applications Reported: The MEL-14 antibody has been reported for use in flow cytometric analysis.Applications Tested: The MEL-14 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.

数据

CD62L (L-Selectin) Antibody (11-0621-81) in FlowStaining of mouse bone marrow with 0.25 µg of Anti-Mouse CD62L (L-Selectin) FITC and PE (right). Autofluorescence is shown as the open histogram. Cells in the myeloid population was used for analysis.

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参考文献：

1.F1000ResearchMyelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms."Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 11-0621-82) in Flow Cytometry"2.Frontiers in immunologyLenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma."11-0621 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma."AuthorsVo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ3.OncoimmunologyInterleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models."11-0621 was used in Flow cytometry/Cell sorting to investigate the efficacy of immune-modulatory interleukin-21 combined with checkpoint blockade in several syngeneic mouse tumor models."AuthorsLewis KE,Selby MJ,Masters G,Valle J,Dito G,Curtis WR,Garcia R,Mink KA,Waggie KS,Holdren MS,Grosso JF,Korman AJ,Jure-Kunkel M,Dillon SR4.Nature communicationsHelminth-induced IL-4 expands bystander memory CD8+T cells for early control of viral infection."Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 11-0621-82) in Flow Cytometry"5.Nature communicationsBcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma."11-0621 was used in Flow cytometry/Cell sorting to establish novel roles for Bcl11b in the regulatory loop that licenses Th2 program in vivo."AuthorsLorentsen KJ,Cho JJ,Luo X,Zuniga AN,Urban JF,Zhou L,Gharaibeh R,Jobin C,Kladde MP,Avram D

技术参数

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