CD62L (L-Selectin) Monoclonal Antibody (DREG-56 (DREG56)), FITC

货号：11-0629-41,11-0629-42

规格：25 Tests,100 Tests

价格：851,2028

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：小鼠

抗体亚型：IgG

克隆号：DREG-56 (DREG56)

荧光染料：FITC

类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC
浓度：	5 µL/Test	用法：	5 μL (1 μg)/test(Flow)

产品详细信息Description: The DREG-56 monoclonal antibody reacts with human CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCAM-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.Applications Reported: The DREG-56 (DREG56) antibody has been reported for use in flow cytometric analysis.Applications Tested: The DREG-56 (DREG56) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.

数据

CD62L (L-Selectin) Antibody (11-0629-41) in FlowStaining of normal human peripheral blood cells with Anti-Human CD4 APC (Product # 17-0049-42) and Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (left) or Anti-Human CD62L (L-Selectin) FITC (right). Cells in the lymphocyte gate were used for analysis.

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参考文献：

1.OncoimmunologyCRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer."11-0629 was used in Flow cytometry/Cell sorting to study PD-1/PD-L1-mediated immune tolerance of Epstein-Barr virus-associated gastric cancer and provide a new strategy to break the tolerance for the T cell-based adoptive therapy."AuthorsSu S,Zou Z,Chen F,Ding N,Du J,Shao J,Li L,Fu Y,Hu B,Yang Y,Sha H,Meng F,Wei J,Huang X,Liu B2.Molecular medicine reportsn-butanol extract from Foliumisatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils."Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 11-0629-42) in Flow Cytometry"3.Scientific reportsHuman uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy."11-0629 was used in Flow cytometry/Cell sorting to immunophenotype lymphocytes from endometrium, term decidua parietalis, and peripheral blood mononuclear cells for direct comparison."AuthorsFeyaerts D,Benner M,van Cranenbroek B,van der Heijden OWH,Joosten I,van der Molen RG4.The Journal of clinical investigationAccelerated resolution of inflammation underlies sex differences in inflammatory responses in humans."Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 11-0629-42) in Flow Cytometry"5.Scientific reportsHuman uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy."11-0629 was used in Flow cytometry/Cell sorting to immunophenotype lymphocytes from endometrium, term decidua parietalis, and peripheral blood mononuclear cells for direct comparison."AuthorsFeyaerts D,Benner M,van Cranenbroek B,van der Heijden OWH,Joosten I,van der Molen RG

技术参数

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