OCT4 Polyclonal Antibody

货号：PA5-27438

规格：100 µL

价格：5841

产品类型：干细胞鉴定

品牌：Thermo Fisher

类型:	一抗	同型对照：
浓度：	0.49 mg/mL	用法：	1:50-1:200 (Flow) ;1:100-1:1000(ICC);1:100-1:1000(IF);Assay Dependent(IHC(F)); 1:100-1:1000(IHC(P));1:500-1:1000(IP);1:5,000-1:100,000(WB)

产品详细信息Recommended positive controls: human ESC, mouse ESC, NT2D1.Predicted reactivity: Mouse (83%), Rat (83%), Cat (94%), Pig (93%), Rabbit (90%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (91%).Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.靶标信息POU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

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参考文献：

1.Oncology lettersUpregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma. 2.Oncology letters Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma.

技术参数

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