Human CD54 (ICAM-1) Recombinant Protein, eBioscience/人CD54（ICAM-1）重组蛋白

货号：BMS313

规格：50 µg

价格：3528

产品类型：蛋白表达研究

品牌：eBioscience

产品详细信息Description: Recombinant soluble ICAM-1 is produced in CHO cells and corresponds in structure with natural human circulating ICAM-1, truncated at the ectodomain side of the beginning of the transmembrane region (aa.472).BMS313 is > 99% pure as demonstrated by SDS-gel electrophoresis.Purity: >99%.Molecular Weight: 82.0 kDa.靶标信息ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

技术参数

产品应用 (Ctrl)Assay-Dependent； (ELISA)Assay-Dependent；(Flow)Assay-Dependent

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