Histone H3 Polyclonal Antibody/组蛋白H3多克隆抗体
货号：PA5-49579
规格：100 µL
价格：4693
产品类型：抗体和染料
品牌：Thermo Fisher
抗原：Peptide sequence around aa.8~12 (R-K-S-T-G) derive
物种：人/小鼠/大鼠
宿主：兔
抗体亚型：IgG
荧光染料：其它
| 类型: | 多抗 | 同型对照： | |
| 浓度： | 1 mg/mL | 用法： | 1.5 µg/1x10^6 cells(ChIP)；1:100-1:200(ICC)；1:100-1:200(IF)；1:1,000(WB) |
产品详细信息The antibody detects endogenous level of total Histone H3 protein.靶标信息Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail ofhistone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
| 数据： |
Histone H3 Antibody (PA5-49579)Antibody specificity was demonstrated through detection of enrichment of the target protein at specific gene loci. Chromatin Immunoprecipitation (ChIP) was performed using anti-H3 polyclonal (Catalog# PA5-49579) with relevant positive and negative target genes/ binding sites. Histone H3 Antibody (PA5-49579) in IFImmunofluorescent analysis of HIST1H3A in methanol-fixed Hela cells. Samples were probed using a HIST1H3A polyclonal antibody (Product # PA5-49579). |
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